Bone Matrix Composition Following PTH Treatment is Not Dependent on Sclerostin Status
نویسندگان
چکیده
منابع مشابه
Efficacy of a sclerostin antibody compared to a low dose of PTH on metaphyseal bone healing.
We compared the effect of a sclerostin antibody to that of a clinically relevant dose of parathyroid hormone (PTH) in a rat model for metaphyseal bone healing. Screws of steel or poly methyl methacrylate (PMMA) were inserted bilaterally into the proximal tibia of young male rats. During 4 weeks the animals then received injections of either phosphate buffered saline (control), sclerostin antibo...
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Sclerosteosis, a skeletal disorder characterized by high bone mass due to increased osteoblast activity, is caused by loss of the SOST gene product, sclerostin. The localization in bone and the mechanism of action of sclerostin are not yet known, but it has been hypothesized that it may act as a bone morphogenetic protein (BMP) antagonist. We show here that SOST/sclerostin is expressed exclusiv...
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Both chronic excess of PTH, as in hyperparathyroidism, and intermittent elevation of PTH (by daily injections) increase the number of osteoblasts. However, whereas the former condition can lead to bone catabolism, intermittent administration of PTH causes bone anabolism. The striking difference between bone loss and bone gain in the two conditions might result from a negative vs. positive balan...
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We present a new, two-pool, linear, time-varying model to describe the short term dynamics of the Ca-PTH axis. We use an asymmetrical reverse sigmoid PTH secretion rate function in the model. This results in an asymmetrical reverse sigmoid relationship between plasma Ca++ and plasma parathyroid hormone (PTH) concentrations (Ca-PTH relationship). In the first validation of this kind, with parame...
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ژورنال
عنوان ژورنال: Calcified Tissue International
سال: 2015
ISSN: 0171-967X,1432-0827
DOI: 10.1007/s00223-015-0074-6